![]() The methylation statuses of the three genes in peripheral blood plasma were detected by fluorescence polymerase chain reaction, and the relationships between the positive rates of the three combined genes with pathology and/or gastroscopy results were analyzed. The patients were divided into two groups: gastric adenocarcinoma group, and control group which are not gastric adenocarcinoma according to pathological or gastroscopic results. Further analysis was done using biopsies collected through gastroscopy at Shanxi Cancer Hospital from Januto February 22, 2021. Screening results combined with literature reports identified three genes ( RPRM, SDC2, and TCF4). Methods: Differential expressed genes (DEGs) were selected from the Gene Expression Omnibus database, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed using DAVID, and a protein-protein interaction network was constructed. Objective: To explore the clinical value of the combined screening of the methylation statuses of the RPRM, SDC2, and TCF4 genes in plasma of gastric cancer patients. Jianghong Guo, Jing Li, Jiang Chang, Li Wang, Yanfeng Xiĭepartment of Pathology, Cancer Hospital Affiliated to Shanxi Medical University, Shanxi Province Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Taiyuan, People’s Republic of ChinaĬorrespondence: Yanfeng Xi, Email ![]()
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